Overview of phospholipids and lipid derivatives
Using the latest synthetic and purification technologies, NOF manufactures and supplies highly purified phospholipids and phospholipid derivatives (COATSOME®
series) suitable for lipid emulsion formulation and liposome formulation which are extensively used for pharmaceuticals and cosmetics. Various kinds and grades of such phospholipids are readily available. Bulk phospholipids are produced in the facility under GMP operation and have been supplying worldwide for many decades with a high reputation. In addition, we can respond to requests from our customers with custom synthesis of any phospholipid with the desired structures.
Products Line of phospholipids and lipid derivatives
NOF supplies purified egg PC, egg PG, soy PC, hydrogenated soy PC and sphingomyelin for natural phospholipids.
Regarding synthetic phospholipids, DDPC, DLPC, DMPC, DPPC, DSPC, DOPC, POPC and DEPC are available in PC series. DMPG, DPPG, DSPG and POPG are available in PG series. DMPA, DPPA and DSPA are available in PA series. DMPE, DPPE, DSPE and DOPE are available in PE series. DOPS is available in PS series in stock. PEG or polyglycerin attached phospholipids (PG phospholipid) are available for long circulating liposome formulation. For non injectable use, DPPC, POPC and POPG are recommended for pulmonary delivery while DOPC, POPC and DDPC are recommended for nasal delivery.
Activated functional group attached phospholipids, either PEG end or non-PEG end, are also available for immunoliposome or targeting use liposome.
NOF provides unique liposome research kits (Empty liposome) for drug delivery systems (DDS). Drug can be very easily encapsulate in the Empty liposome.
NOF has developed novel lipid derivatives which have high drug delivery efficiency.
Please click followings in detail.
Manufacturing Capability of NOF Phospholipids
cGMP Manufacturing Facility
NOF Phospholipids are manufactured in facility under cGMP operation and have been supplied worldwide for many years with good reputation.
Drug Master Files of Phospholipids
NOF has already submitted 19 DMFs regarding many kinds of phospholipids to US FDA so that customers rely on our quality. We submit DMF according to customer's request and development.
Research & Development of Lipids
Our R&D facility was opened in December 2005. This allows us to continue our development of novel phospholipids and lipids such as SS-cleavable lipid and Polyglycerin-phospholipid.