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PEGylated Lipids

PEGylated lipids can be applied to liposomal drug formulations to prolong the plasma half-life of the drugs. Coating of the liposomal surface with polyethylene glycol would suppress the uptake of the drug by the reticuloendothelial system, thereby prolonging the half-life of the drug in the plasma. PEG-modified lipids can also be used as emulsifiers and stabilizers of microspheres in aqueous solutions.