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pH-Trigger Releasable PEGs

Overview of pH Trigger releasable PEG

NOF has provided pH-trigger releasable PEG derivatives having pH-cleavable acetyl linkers. The linkers can be cleaved at mildly acidic environment, such as endosomes, lysosomes, or tumor tissues, releasing the pharmaceutical substances conjugated to the linkers. The release rate of the pharmaceutical substances can be adjusted appropriately with different substituents on the benzene ring. The highly tunable linker technology is also applicable to hetero-type PEG derivatives which are useful as linkers for Antibody-Drug Conjugates (ADCs).

Molecular structure of pH Trigger releasable PEG


Products line of pH Trigger releasable PEG

Product name

Functional Group :X

MW

SUNBRIGHT ME-3E050FH-TS*

Succinimidylcarbonate

O-CO2-NHS

5,000

SUNBRIGHT ME-3E200FH-TS*

20,000

SUNBRIGHT ME-3E050FH-EA*

Amine

- NH2

5,000

SUNBRIGHT ME-3E200FH-EA*

20,000

SUNBRIGHT ME-3E050FH-MA*

Maleimide

NHCO-(CH2)2- Maleimide

5,000

SUNBRIGHT ME-3E200FH-MA*

20,000



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