NOF has developed novel degradable PEGs that have enzyme cleavable peptide linkers.
Degradable PEGs have the same blood circulation time as non-degradable PEGs and are removed from the body faster than non-degradable PEGs, because they are cleaved to lower molecular weight PEG in cell.
- 9-1. Linear Type (SUNBRIGHT® LP4 series)
- 9-2. Branched Type
Degradable PEGs in cells were completely degraded by intracellular enzymes.
Additionally, degradable PEGs were stable in the serum as same as non-degradable PEGs.
(A)Degradable PEG has the same blood circulation time as non-degradable mPEG(40kDa).
(B)Degradable PEG was removed from the body faster than non-degradable mPEG(40kDa), because it was cleaved from 40kDa to 20kDa in cell.