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10. Biodegradable Polymers for gene/nucleic acid Delivery SUNBRIGHT® ME-DT and DT Series

NOF has provided new biodegradable polymers for gene/nucleic acid delivery, SUNBRIGHT® ME-DT and DT Series. The poly cationic block polymer, PEG-PAsp(DET) (polyethylene glycol-b-poly{N’-[N-(2-aminoethyl)-2-aminoethyl] aspartamide}), and homo polymer, PAsp(DET) forming polymeric micelles with polyanions such as gene/nucleic acid (ex. plasmid DNA and mRNA) enable efficient delivery of gene/nucleic acid with a low toxicity compared to conventional cationic carriers.

Formation of Polymeric Micelles by SUNBRIGHT® ME-DT, DT Series and plasmid DNA.

Figure.1 Formation of polymer micelles through the electrostatic interaction between SUNBRIGHT® ME-DT (PEG-PAsp(DET) Block) / SUNBRIGHT® DT (PAsp(DET) Homo polymer) and plasmid DNA.


Effective Endosmal Membrane Disruption Responding to Acidic pH in Endosomal Compartment

Figure.2 Protonation behavior and membrane disruption activity of SUNBRIGHT® ME-DT Series (PEG-PAsp(DET) Block).

Smooth delivery to cytoplasm

Figure.3 Protonation behavior and membrane disruption activity of SUNBRIGHT® ME-DT Series (PEG-PAsp(DET) Block)

K. Miyata et al. J. Am. Chem. Soc. 130 :16287-16294 (2008)

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