Solubilizer SL-11, occurring as a transparent liquid, can be used to prepare nano-emulsions of various hydrophobic drugs (particle sizes are below 50 nm). Since this possesses excellent self-emulsifying property, this is the most appropriate agent for SEDDS (Self Emulsifying Drug Delivery Systems). Following oral administration, this solubilizer SL-11 augments intestinal absorption of drugs. Once hydrophobic drug is dissolved in SL-11 as directed in the attached protocol, SEDDS reagent containing the drug can be easily prepared. NOF has also capability of the toll development by using this technology.
・ Easy preparation
・ Applicable to various kinds of hydrophobic drugs
・ Applicable to soft capsules for oral use
・ Most suitable for SEDDS agent
・ Improvement of intestinal absorption following oral administration
・ Comply with toll development for formulations
・ Comply with bulk supply requests
1.Dissolve drug in a suitable solvent, such as ethanol, etc.
2.Add the drug solution prepared in 1 to Solubilizer SL-11, thoroughly mix to completely dissolve the contents.
3.The drug/SL-11 solution with solvent is made.
4.Evaporate the solvent at 50°C for about 1 hour to remove the solvent, or remove the solvent under a nitrogen stream.
5.Concentrated solution of SL-11 and the drug is made.
6.Soft capsules can be prepared by using the concentrated solution in 5.
2. Depending on the drug, it can be dissolved directly in SL-11. If required, warm the solution about 50˚C to dissolve completely.
5. The concentrated solution of SL-11 and the drug is made.
6. Soft capsules can be prepared by using the concentrated solution in 5 .
Remarks: *Temperature may be changed depending upon the drug stability.