An Innovative Lipid for the Formulation of Lipid Nanoparticles (LNPs)
NOF CORPORATION would like to announce the launch of innovative lipid for nucleic acid and gene delivery, COATSOME® SS-OP, for the formulation of lipid nanoparticles (LNPs). COATSOME® SS-OP can make LNPs having high efficiency of intracellular delivery.
COATSOME® SS-OP has phenyl ester bonds which enhance degradability of own structure in intracellular environment, tertiary amino groups which induce endosomal escape, and a disulfide bond which cleaves in reductive environment.
Key advantages of COATSOME® SS-OP are:
· pDNA, mRNA and siRNA can be encapsulated with high efficiency.
· Enhanced degradability in intracellular environment makes high delivery efficiency of nucleic acids.
· Nucleic acids can be delivered with high selectivity to specific tissues such as liver, lymph node, spleen or tumor.
The high degradability of COATSOME® SS-OP in intracellular environment improves performance and safety of nucleic acid drugs and gene therapy drugs.
For more information, contact our regional offices.
NOF EUROPE GmbH
NOF AMERICA CORPORATION
Tel: NY Office: +1-914-681-9790 (Ext. 120)
CA Office: +1-949-253-5764
[Asia Pacific, Japan]
DDS Development Division
NOF (Shanghai) Co. Ltd.
No posts found