An Innovative Lipid for the Formulation of Lipid Nanoparticles (LNPs)

12/13/2018
by NOF EUROPE GmbH

NOF CORPORATION would like to announce the launch of innovative lipid for nucleic acid and gene delivery, COATSOME® SS-OP, for the formulation of lipid nanoparticles (LNPs). COATSOME® SS-OP can make LNPs having high efficiency of intracellular delivery.

COATSOME® SS-OP has phenyl ester bonds which enhance degradability of own structure in intracellular environment, tertiary amino groups which induce endosomal escape, and a disulfide bond which cleaves in reductive environment.

Key advantages of COATSOME® SS-OP are:

· pDNA, mRNA and siRNA can be encapsulated with high efficiency.

· Enhanced degradability in intracellular environment makes high delivery efficiency of nucleic acids.

· Nucleic acids can be delivered with high selectivity to specific tissues such as liver, lymph node, spleen or tumor.

The high degradability of COATSOME® SS-OP in intracellular environment improves performance and safety of nucleic acid drugs and gene therapy drugs.

For more information, contact our regional offices.


[Europe]

NOF EUROPE GmbH

E-mail: info@nofeurope.com

Tel: +49-69-7706-100-0


[Americas]

NOF AMERICA CORPORATION

E-mail: info@nofamerica.com

Tel: NY Office: +1-914-681-9790 (Ext. 120)


CA Office: +1-949-253-5764


[Asia Pacific, Japan]

NOF CORPORATION

DDS Development Division

E-mail: ddsinfo@nof.co.jp


[China]

NOF (Shanghai) Co. Ltd.

E-mail: info@nof.cn

Tel: +86-21-6210-1100

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