ON-DEMAND TALK

CRS 2021 Annual Meeting

On-demand Talk –VIRTUAL– (JULY 25 – 29, 2021)

06/16/2021 by NOF EUROPE GmbH

NOF CORPORATION will present NOF DDS technology for mRNA Vaccines at CRS 2021 ANNUAL MEETING –VIRTUAL– to be held from July 25 to 29, 2021.

Conference Website: https://2021.controlledreleasesociety.org

Presentation Title: Interaction of LNP-mRNA Vaccines with Immune Effector Cells: Implications for Development of a Single Dose mRNA Vaccine

Abstract:
Messenger RNA based vaccines delivered with lipid nanoparticles have recently emerged as a leading strategy for treatment of infectious disease including COVID-19. One major drawback of the two current approved vaccines is that they require two doses to achieve a full antibody response. Here we characterize immune responses to a novel biodegradable lipid platform, COATSOME® SS-Lipid, for mRNA vaccines. We showed evidence of robust T-cell responses with a single shot mRNA-LNP vaccine, consistent with presentation of exogenous mRNA antigens in the MHC-I complex. Our current efforts are focused on creating improved LNP systems for targeting of dendritic cells to enable single dose mRNA vaccines.

On-Demand Talk will be available for viewing starting 2 weeks before the conference.

Please contact our regional offices below for the detail of the presentation or if you have any questions about the contents of the presentation.