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Degradable PEGs

Degradable PEGs

NOF has developed novel degradable PEGs that have enzyme cleavable peptide linkers. Degradable PEGs have the same blood circulation time as non-degradable PEGs and are removed from the body faster than non-degradable PEGs, because they are cleaved to lower molecular weight PEG in cell.

      Degradation test in vitro

      Degradability

      GPC Chromatograms

      Degradable PEGs in cells were completely degraded by intracellular enzymes.
      Additionally, degradable PEGs were stable in the serum as same as non-degradable PEGs.

      Pharmacokinetic test in vivo

      (A)Degradable PEG has the same blood circulation time as non-degradable mPEG(40kDa).

      (B)Degradable PEG was removed from the body faster than non-degradable mPEG(40kDa), because it was cleaved from 40kDa to 20kDa in cell.

      Linear Type Degradable PEGs

      SUNBRIGHT® LP4 Series

      SUNBRIGHT® LP4-400MA2

      Degradable PEGs, MW=40,000 (20,000×2)
      Packaging size: 0.1g / 1g

      SUNBRIGHT® LP4-400GS2

      Degradable PEGs, MW=40,000 (20,000×2)
      Packaging size: 0.1g / 1g

      SUNBRIGHT® LP4-400AL2

      Degradable PEGs, MW=40,000 (20,000×2)
      Packaging size: 0.1g / 1g

      Branched Type Degradable PEGs

      2-arm Branched PEGs (SUNBRIGHT® BP2 series)

      SUNBRIGHT® BP2-400MA2

      Degradable PEGs, Branched Type, 2-arm Branched MW=40,000 (20,000×2)
      Packaging size: 0.1g / 1g

      SUNBRIGHT® BP2-400TS2

      Degradable PEGs, Branched Type, 2-arm Branched MW=40,000 (20,000×2)
      Packaging size: 0.1g / 1g

      SUNBRIGHT® BP2-400AL2

      Degradable PEGs, Branched Type, 2-arm Branched MW=40,000 (20,000×2)
      Packaging size: 0.1g / 1g

      4-arm Branched PEGs (SUNBRIGHT® 4BP2 series)

      SUNBRIGHT® 4BP2-400MA4

      Degradable PEGs, Branched Type, 4-arm Branched MW=40,000 (10,000×4)
      Packaging size: 0.1g / 1g

      SUNBRIGHT® 4BP2-400TS4

      Degradable PEGs, Branched Type, 4-arm Branched MW=40,000 (10,000×4)
      Packaging size: 0.1g / 1g

      SUNBRIGHT® 4BP2-400AL4

      Degradable PEGs, Branched Type, 4-arm Branched MW=40,000 (10,000×4)
      Packaging size: 0.1g / 1g