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Highly-purified Synthetic Phospholipids

Highly-purified Synthetic Phospholipids

We use fatty acids that are highly purified by our own technologies for the manufacture of a variety of phospholipid derivatives; that is, NOF can synthesize derivatives containing a variety of fatty acids. Our phospholipids are manufactured in FDA-inspected facilities meeting GMP standards. Our quality-assured products can be safely used for the production of pharmaceuticals. 

NOF as a contracted manufacturer also synthesizes novel phospholipid derivatives and has completed DMF registrations for numerous novel derivatives; we are in a position to supply relevant lipids from test reagent grade to commercial production scales that are approved for manufacture of pharmaceuticals after clinical studies.

Phosphatidylcholine

Phospholipids are the primary constituents of biological membranes. Recently, phospholipids have been directly implicated in the important biological functions as well as biomembrane structure. Sphingomyelin in particular was found to be vital for formation and maintenance of lipid rafts, where immune responses, various kinds of signaling, and certain material transport take place. Sphingomyelin is thus involved in expression of specific cellular functions, such as intracellular information transmission and maintenance of membrane structure. Sphingomyelin, with long fatty acid chains and low phase transition temperatures (Tc), is easy to prepare into liposomes. Highly pure sphingomyelin of either the milk or yolk origin is available from NOF.

Sphingomyelin from yolk has fatty acid chains consisting of about 80% palmitic acid joined by amide bonds, while that from milk contains many kinds of fatty acids whose chains are longer than palmitic acid. These two sphingomyelin products slightly differ in physical properties, and can be selected according to needs.

Phosphatidylcholine

COATSOME® MC-1010 (DDPC)

Acronym: DDPC
Chemical Name: 1,2-Didecanoyl-sn-glycero-3-phosphocholine
CAS#: 3436-44-0
PC purity: 99% up
Molecular weight: 565.7
Alkyl composition: R1COO= C10:0, R2COO= C10:0
Tc: -6
Package size: 1g / 10g

COATSOME® MC-4040 (DMPC)

Acronym: DMPC
Chemical Name: 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
CAS#: 18194-24-6
PC purity: 99% up
Molecular weight: 677.9
Alkyl composition: R1COO= C14:0, R2COO= C14:0
Tc: 23
Package size: 1g / 10g

COATSOME® MC-6060 (DPPC)

Acronym: DPPC
Chemical Name: 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine
CAS#: 63-89-8
PC purity: 99% up
Molecular weight: 734
Alkyl composition: R1COO= C16:0, R2COO= C16:0
Tc: 41
Package size: 1g / 10g

COATSOME® MC-8080 (DSPC)

Acronym: DSPC
Chemical Name: 1,2-Distearoyl-sn-glycero-3-phosphocholine
CAS#: 816-94-4
PC purity: 99% up
Molecular weight: 790.2
Alkyl composition: R1COO= C18:0, R2COO= C18:0
Tc: 55
Package size: 1g / 10g

COATSOME® MC-8282 (DLoPC)

Acronym: DLoPC
Chemical Name: 1,2-Dilinoleoyl-sn-glycero-3-phosphocholine
CAS#: 998-06-1
PC purity: 99% up
Molecular weight: 782.2
Alkyl composition: R1COO= C18:2, R2COO= C18:2
Package size: 1g
Tc: -53

COATSOME® MC-8181 (DOPC)

Acronym: DOPC
Chemical Name: 1,2-Dioleoyl-sn-glycero-3-phosphocholine
CAS#: 4235-95-4
PC purity: 99% up
Molecular weight: 786.1
Alkyl composition: R1COO= C18:1, R2COO= C18:1
Tc: -22
Package size: 1g / 10g

COATSOME® MC-2121AL (DEPC)

Acronym: DEPC
Chemical Name: 1,2-Dierucoyl-sn-glycero-3-phosphocholine
CAS#: 56649-39-9
PC purity: 99% up
Molecular weight: 898.3
Alkyl composition: R1COO= C22:1, R2COO= C22:1
Tc: -13
Package size: 1g / 10g

COATSOME® MC-4060* (MPPC)

Acronym: MPPC
Chemical Name: 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine
PC purity: 99% up
Molecular weight: 706
Alkyl composition: R1COO= C14:0, R2COO= C16:0
Tc: 35
Package size: 1g / 10g

COATSOME® MC-4080* (MSPC)

Acronym: MSPC
Chemical Name: 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine
CAS#: 76343-22-1
PC purity: 99% up
Molecular weight: 734
Alkyl composition: R1COO= C14:0, R2COO= C18:0
Tc: 40
Package size: 1g / 10g
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COATSOME® MC-6040* (PMPC)

Acronym: PMPC
Chemical Name: 1-Palmitoyl-2-myristoyl-sn-glycero-3-phosphocholine
CAS#: 69441-09-4
PC purity: 99% up
Molecular weight: 706
Alkyl composition: R1COO= C16:0, R2COO= C14:0
Tc: 28
Package size: 1g /10g

COATSOME® MC-6080* (PSPC)

Acronym: PSPC
Chemical Name: 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine
CAS#: 59403-51-9
PC purity: 99% up
Molecular weight: 762.1
Alkyl composition: R1COO= C16:0, R2COO= C18:0
Tc: 49
Package size: 1g / 10g

COATSOME® MC-6081 (POPC)

Acronym: POPC
Chemical Name: 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
CAS#: 26853-31-6
PC purity: 99% up
Molecular weight: 760.1
Alkyl composition: R1COO= C16:0, R2COO= C18:1
Tc: -3
Package size: 1g / 10g

COATSOME® MC-8081 (SOPC)

Acronym: SOPC
Chemical Name: 1-Stearoyl-2-oleoyl-sn-glycero-3-phosphocholine
CAS#: 56421-10-4
PC purity: 99% up
Molecular weight: 788.1
Alkyl composition: R1COO= C18:0, R2COO= C18:1
Tc: 6
Package size: 1g / 10g

Lyso-Phosphatidylcholine

Lyso-Phosphatidylcholine

COATSOME® MC-40H (M-LysoPC)

Acronym: M-LysoPC
Chemical Name: 1-Myristoyl-2-lyso-sn-glycero-3-phosphocholine
CAS#: 20559-16-4
PC purity: 99% up
Molecular weight: 467.6
Alkyl composition: R1COO= C14:0
Package size: 1g / 10g

COATSOME® MC-60H (P-LysoPC)

Acronym: P-LysoPC
Chemical Name: 1-Palmitoyl-2-lyso-sn-glycero-3-phosphocholine
CAS#: 17364-16-8
PC purity: 99% up
Molecular weight: 495.6
Alkyl composition: R1COO= C16:0
Package size: 1g / 10g

COATSOME® MC-80H (S-LysoPC)

Acronym: S-LysoPC
Chemical Name: 1-Stearoyl-2-lyso-sn-glycero-3-phosphocholine
CAS#: 19420-57-6
PC purity: 99% up
Molecular weight: 523.7
Alkyl composition: R1COO= C18:0
Package size: 1g / 10g

COATSOME® MC-81H (O-LysoPC)

Acronym: O-LysoPC
Chemical Name: 1-Oleoyl-2-lyso-sn-glycero-3-phosphocholine
CAS#: 19420-56-5
PC purity: 99% up
Molecular weight: 521.7
Alkyl composition: R1COO= C18:1
Package size: 1g / 10g

Phosphatidylglycerol

Phosphatidylglycerol

COATSOME® MG-4040LS (DMPG-Na)

Acronym: DMPG-Na
Chemical Name: 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol, sodium salt
CAS#: 67232-80-8
PG purity: 99% up
Molecular weight: 689.9
Alkyl composition: R1COO= C14:0, R2COO= C14:0
Package size: 1g / 10g

COATSOME® MG-4040LA (DMPG-NH4)

Acronym: DMPG-NH4
Chemical Name: 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol, ammonium salt
CAS#: 108321-03-5
PG purity: 99% up
Molecular weight: 683.9
Alkyl composition: R1COO= C14:0, R2COO= C14:0
Package size: 1g / 10g

COATSOME® MG-6060LS (DPPG-Na)

Acronym: DPPG-Na
Chemical Name: 1,2-Dipalmitoyl-sn-glycero-3-phosphoglycerol, sodium salt
CAS#: 67232-81-9
PG purity: 99% up
Molecular weight: 745
Alkyl composition: R1COO= C16:0, R2COO= C16:0
Package size: 1g / 10g

COATSOME® MG-6060LA (DPPG-NH4)

Acronym: DPPG-NH4
Chemical Name: 1,2-Dipalmitoyl-sn-glycero-3-phosphoglycerol, ammonium salt
CAS#: 73548-70-6
PG purity: 98% up
Molecular weight: 740
Alkyl composition: R1COO= C16:0, R2COO= C16:0
Package size: 1g / 10g

COATSOME® MG-8080LS (DSPG-Na)

Acronym: DSPG-Na
Chemical Name: 1,2-Distearoyl-sn-glycero-3-phosphoglycerol, sodium salt
CAS#: 67232-82-0
PG purity: 99% up
Molecular weight: 801.1
Alkyl composition: R1COO= C18:0, R2COO= C18:0
Package size: 1g / 10g

COATSOME® MG-8181LS (DOPG-Na)

Acronym: DOPG-Na
Chemical Name: 1,2-Dioleoyl-sn-glycero-3-phosphoglycerol, sodium salt
CAS#: 67254-28-8
PG purity: 98% up
Molecular weight: 797
Alkyl composition: R1COO= C18:1, R2COO= C18:1
Package size: 1g / 10g

COATSOME® MG-6081LS (POPG-Na)

Acronym: POPG-Na
Chemical Name: 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, sodium salt
CAS#: 268550-95-4
PG purity: 98% up
Molecular weight: 771
Alkyl composition: R1COO= C16:0, R2COO= C18:1
Package size: 1g / 10g

Phosphatidic acid

Phosphatidic acid

COATSOME® MA-4040LS (DMPA-Na)

Acronym: DMPA-Na
Chemical Name: 1,2-Dimyristoyl-sn-glycero-3-phosphatidic acid, sodium salt
CAS#: 80724-31-8
PA purity: 98% up
Molecular weight: 614.8
Alkyl composition: R1COO= C14:0, R2COO= C14:0
Package size: 1g / 10g

COATSOME® MA-6060LS (DPPA-Na)

Acronym: DPPA-Na
Chemical Name: 1,2-Dipalmitoyl-sn-glycero-3-phosphatidic acid, sodium salt
CAS#:169051-60-9  
PA purity: 99% up
Molecular weight: 670.9
Alkyl composition: R1COO= C16:0, R2COO= C16:0
Package size: 1g / 10g

COATSOME® MA-8080LS (DSPA-Na)

Acronym: DSPA-Na
Chemical Name: 1,2-Distearoyl-sn-glycero-3-phosphatidic acid, sodium salt
CAS#: 108321-18-2
PA purity: 99% up
Molecular weight: 727
Alkyl composition: R1COO= C18:0, R2COO= C18:0
Package size: 1g / 10g

Phosphatidylethanolamine

Phosphatidylethanolamine

COATSOME® ME-4040 (DMPE)

Acronym: DMPE
Chemical Name: 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine
CAS#: 988-07-2
PE purity: 99% up
Molecular weight: 635.9
Alkyl composition: R1COO= C14:0, R2COO= C14:0
Package size: 1g / 10g

COATSOME® ME-6060 (DPPE)

Acronym: DPPE
Chemical Name: 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine
CAS#: 923-61-5
PE purity: 99% up
Molecular weight: 692
Alkyl composition: R1COO= C16:0, R2COO= C16:0
Package size: 1g / 10g

COATSOME® ME-8080 (DSPE)

Acronym: DSPE
Chemical Name: 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine
CAS#: 1069-79-0
PE purity: 99% up
Molecular weight: 748.1
Alkyl composition: R1COO= C18:0, R2COO= C18:0
Package size: 1g / 10g

COATSOME® ME-8181 (DOPE)

Acronym: DOPE
Chemical Name: 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
CAS#: 4004-05-1
PE purity: 99% up
Molecular weight: 744
Alkyl composition: R1COO= C18:1, R2COO= C18:1
Package size: 1g / 10g

COATSOME® ME-8282 (DLoPE)

Acronym: DLoPE
Chemical Name: 1,2-Dilinoleoyl-sn-glycero-3-phosphoethanolamine
CAS#: 20707-71-5
PE purity: 99% up
Molecular weight: 740
Alkyl composition: R1COO= C18:2, R2COO= C18:2
Package size: 1g / 10g

COATSOME® ME-6081 (POPE)

Acronym: POPE
Chemical Name: 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine
CAS#: 26662-94-2
PE purity: 99% up
Molecular weight: 718
Alkyl composition: R1COO= C16:0, R2COO= C18:1
Package size: 1g / 10g

Phosphatidylserine

Phosphatidylserine

COATSOME® MS-4040LS (DMPS-Na)

Acronym: DMPS-Na
Chemical Name: 1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine, sodium salt
CAS#: 105405-50-3
PS purity: 85% up
Molecular weight: 701.8
Alkyl composition: R1COO= C14:0, R2COO= C14:0
Package size: 1g / 10g

COATSOME® MS-6060LS (DPPS-Na)

Acronym: DPPS-Na
Chemical Name: 1,2-Dipalmitoyl-sn-glycero-3-phospho-L-serine, sodium salt
CAS#: 145849-32-7
PS purity: 85% up
Molecular weight: 758
Alkyl composition: R1COO= C16:0, R2COO= C16:0
Package size: 1g / 10g

COATSOME® MS-8080LS (DSPS-Na)

Acronym: DSPS-Na
Chemical Name: 1,2-Distearoyl-sn-glycero-3-phospho-L-serine, sodium salt
CAS#: 321595-13-5
PS purity: 85% up
Molecular weight: 814.1
Alkyl composition: R1COO= C18:0, R2COO= C18:0
Package size: 1g / 10g

COATSOME® MS-8181LS (DOPS-Na)

Acronym: DOPS-Na
Chemical Name: 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine, sodium salt
CAS#: 70614-14-1
PS purity: 97% up
Molecular weight: 810
Alkyl composition: R1COO= C18:1, R2COO= C18:1
Package size: 1g / 10g

COATSOME® MS-6081LS (POPS-Na)

Acronym: POPS-Na
Chemical Name: 1-Palmitoyl-2-oleoyl-sn-3-phospho-L-serine, sodium salt
CAS#: 321863-21-2
PS purity: 85% up
Molecular weight: 784
Alkyl composition: R1COO= C16:0, R2COO= C18:1
Package size: 1g / 10g

Activated phospholipids

Activated phospholipids include both maleimide groups reactive with -SH groups in biologics, and activated carboxylic esters which react with -NH2 and -SH groups in proteins.

MAL-Phospholipid

COATSOME® FE-4040MA3 (DMPE-MAL)

Acronym: DMPE-MAL
Chemical Name: N-(3-Maleimide-1-oxopropyl)-L-α-phosphatidylethanolamine, Dimyristoyl
CAS#: None
Molecular weight: 809
Alkyl composition: R1COO= C14:0, R2COO= C14:0
Package size: 0.1g / 1g / 10g

COATSOME® FE-6060MA3 (DPPE-MAL)

Acronym: DPPE-MAL
Chemical Name: N-(3-Maleimide-1-oxopropyl)-L-α-phosphatidylethanolamine, Dipalmitoyl
CAS#: None
Molecular weight: 865.1
Alkyl composition: R1COO= C16:0, R2COO= C16:0
Package size: 0.1g / 1g / 10g

COATSOME® FE-8080MA3 (DSPE-MAL)

Acronym: DSPE-MAL
Chemical Name: N-(3-Maleimide-1-oxopropyl)-L-α-phosphatidylethanolamine, Distearoyl
CAS#: None
Molecular weight: 921.2
Alkyl composition: R1COO= C18:0, R2COO= C18:0
Package size: 0.1g / 1g / 10g

COATSOME® FE-6081MA3 (POPE-MAL)

Acronym: POPE-MAL
Chemical Name: N-(3-Maleimide-1-oxopropyl)-L-α-phosphatidylethanolamine, 1-Palmitoyl-2-oleoyl
CAS#: None
Molecular weight: 891.1
Alkyl composition: R1COO= C16:0, R2COO= C18:1
Package size: 0.1g / 1g / 10g

COATSOME® FE-8181MA3 (DOPE-MAL)

Acronym: DOPE-MAL
Chemical Name: N-(3-Maleimide-1-oxopropyl)-L-α-phosphatidylethanolamine, Dioleoyl
CAS#: None
Molecular weight: 917.1
Alkyl composition: R1COO= C18:1, R2COO= C18:1
Package size: 0.1g / 1g / 10g

NHS-Phospholipid

COATSOME® FE-8181SU5 (DOPE-NHS)

Acronym: DOPE-NHS
Chemical Name: N-(Succinimidyloxy-glutaryl)-L-α-phosphatidylethanolamine, Dioleoyl
CAS#:
Molecular weight: 977.2
Alkyl composition: R1COO= C18:1, R2COO= C18:1
Package size: 0.1g / 1g / 10g

COATSOME® FE-4040SU5 (DMPE-NHS)

Acronym: DMPE-NHS
Chemical Name: N-(Succinimidyloxy-glutaryl)-L-α-phosphatidylethanolamine, Dimyristoyl
CAS#:
Molecular weight: 869
Alkyl composition: R1COO= C14:0, R2COO= C14:0
Package size: 0.1g / 1g / 10g

COATSOME® FE-6060SU5 (DPPE-NHS)

Acronym: DPPE-NHS
Chemical Name: N-(Succinimidyloxy-glutaryl)-L-α-phosphatidylethanolamine, Dipalmitoyl
CAS#: None
Molecular weight: 925.1
Alkyl composition: R1COO= C16:0, R2COO= C16:0
Package size: 0.1g / 1g / 10g

COATSOME® FE-8080SU5 (DSPE-NHS)

Acronym: DSPE-NHS
Chemical Name: N-(Succinimidyloxy-glutaryl)-L-α-phosphatidylethanolamine, Distearoyl
CAS#:
Molecular weight: 981.2
Alkyl composition: R1COO= C18:0, R2COO= C18:0
Package size: 1g

COATSOME® FE-6081SU5 (POPE-NHS)

Acronym: POPE-NHS
Chemical Name: N-(Succinimidyloxy-glutaryl)-L-α-phosphatidylethanolamine, 1-Palmitoyl-2-oleoyl
CAS#:
Molecular weight: 951.2
Alkyl composition: R1COO= C16:0, R2COO= C18:1
Package size: 0.1g / 1g / 10g

Glu-Phospholipid

COATSOME® FE-4040GL (DMPE-Glu)

Acronym: DMPE-Glu
Chemical Name: N-Glutaryl-L-α-phosphatidylethanolamine, Dimyristoyl
CAS#:
Molecular weight: 771.9
Alkyl composition: R1COO= C14:0, R2COO= C14:0
Package size: 1g / 10g

COATSOME® FE-6060GL (DPPE-Glu)

Acronym: DPPE-Glu
Chemical Name: N-Glutaryl-L-α-phosphatidylethanolamine, Dipalmitoyl
CAS#: 474923-45-0
Molecular weight: 828.1
Alkyl composition: R1COO= C16:0, R2COO= C16:0
Package size: 1g / 10g

COATSOME® FE-8080GL (DSPE-Glu)

Acronym: DSPE-Glu
Chemical Name: N-Glutaryl-L-α-phosphatidylethanolamine, Distearoyl
CAS#:
Molecular weight: 884.2
Alkyl composition: R1COO= C18:0, R2COO= C18:0
Package size: 1g / 10g

COATSOME® FE-8181GL (DOPE-Glu)

Acronym: DOPE-Glu
Chemical Name: N-Glutaryl-L-α-phosphatidylethanolamine, Dioleoyl
CAS#:
Molecular weight: 880.1
Alkyl composition: R1COO= C18:1, R2COO= C18:1
Package size: 1g / 10g

COATSOME® FE-6081GL (POPE-Glu)

Acronym: POPE-Glu
Chemical Name: N-Glutaryl-L-α-phosphatidylethanolamine, 1-Palmitoyl-2-oleoyl
CAS#:
Molecular weight: 854.1
Alkyl composition: R1COO= C16:0, R2COO= C18:1
Package size: 1g / 10g

PDP-Phospholipid

COATSOME® FE-6060DT (DPPE-PDP)

Acronym: DPPE-PDP
Chemical Name: N-[3-(2-Pyridinyldithio)-1-oxopropyl]-L-α-phosphatidylethanolamine, Dipalmitoyl
CAS#:
Molecular weight: 911.2
Alkyl composition: R1COO= C16:0, R2COO= C16:0
Package size: 0.1g / 1g