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Single Molecule PEGs

Single Molecule PEGs

PUREBRIGHT® Series

We have the technology to synthesize PEG molecules with a specific number of ethylene oxide units, providing a highly pure product that has a single molecular weight and length. The purity of our products come from purification techniques that we have accumulated from the development of various PEGs.

In addition, we can supply specific length PEGs at various molecular weights and with select architectures (linear or branched type) and functional groups such as maleimide, Boc, azide, as well as amino group and carboxyl group by applying our synthetic techniques developed for standard activated PEGs.

Furthermore, we have reliable test methods to determine the exact purity of the single molecule PEGs with their terminal activity and the number of EG units.

Linear hetero single molecule PEG

Linear hetero single molecule PEG

PUREBRIGHT A-L08-PC

Amino-EG8-C2-Carboxic Acid, MW=441.51
Packaging size: 0.1g / 1g / 10g

PUREBRIGHT A-L12-PC

Amino-EG12-C2-Carboxic Acid, MW=617.72
Packaging size: 0.1g / 1g / 10g

PUREBRIGHT MA-L08-PC*

Maleimide-EG8-C2-Carboxic Acid, MW=592.63
Packaging size: 0.1g / 1g / 10g

PUREBRIGHT MA-L12-PC*

Maleimide-EG12-C2-Carboxic Acid, MW=768.84
Packaging size: 0.1g / 1g / 10g

PUREBRIGHT MA-L08-PS*

Maleimide-EG8-C2-COO-NHS, MW=689.71
Packaging size: 0.1g / 1g

PUREBRIGHT MA-L12-PS*

Maleimide-EG12-C2-COO-NHS, MW=865.92

Packaging size: 0.1g / 1g

PUREBRIGHT BO-L08-PC*

tBOC-EG8-C2-Carboxic Acid, MW=541.63
Packaging size: 0.1g / 1g / 10g

PUREBRIGHT BO-L12-PC*

tBOC-EG12-C2-Carboxic Acid, MW=717.84
Packaging size: 0.1g / 1g / 10g

Branched hetero single molecule PEG

Branched hetero single molecule PEG

PUREBRIGHT B24-2TS-MA

MW=1581.65
Packaging size: 0.1g / 1g / 10g

PUREBRIGHT B24-2TS-AZ*

MW=1555.66
Packaging size: 0.1g / 1g / 10g

PUREBRIGHT B24-2TS-BO*

MW=1530.65
Packaging size: 0.1g / 1g / 10g

Pendant type PEG linker

NOF has developed novel single molecule PEG linkers that have pendant-like structure. The pendant type PEG linkers have two single molecule PEG chains with two different functional groups. The pendant type PEG linkers can improve hydrophilicity of ADCs by effectively masking hydrophobicity of payloads.

We prepared the ADC with the pendant type single molecule PEG linker. We evaluated the hydrophobicity of the ADC by hydrophobic interaction chromatography (HIC) and performed in vivo pharmacokinetic study. The results demonstrated that the pendant type single molecule PEG linker improved hydrophilicity and pharmacokinetics of the ADC more effectively in comparison with the linear type single molecule PEG linker.

Pendant type PEG linker

Pendant type PEG linker

PUREBRIGHT MA-P12-PS

Pendant EG12, Maleimide-Propionic acid NHS ester MW=1640.81
Packaging size: 0.1g / 1g