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NOF to Exhibit and Present Poster at SITC 2024

NOF to Exhibit and Present Poster at SITC 2024

Houston, TX, USA (November 08 - 09, 2024)

10/24/2024

NOF CORPORATION is pleased to announce its participation in the upcoming SITC 2024, which will be held at George R. Brown Convention Center, Houston, TX, U.S.A. from November 6 to 10.

The Conference website: https://www.sitcancer.org/2024...

As a part of the event, NOF CORPORATION will showcase its products for Drug Delivery System at Booth #712 from November 8 to 9.

In addition, Satoshi Kishida, Research Scientist at NOF CORPORATION, will give a poster presentation.


Title
IL-2 mutein conjugated by cutting-edge PEG can improve the antitumor activity of CD8+ T cells in the tumor microenvironment

Date & Time
November 9 from 9:00 to 20:30, CST

Place
Exhibit Halls AB-George R. Brown Convention Center, #948

Speaker
Satoshi Kishida, Research Scientist, NOF CORPORATION

Abstract
IL-2 can activate CD8+ T cells and is well-known as a promising immune- oncology agent. However,
its therapeutic efficacy is limited due to its short half-life and IL-2 receptor alpha (IL-2Ra)
capability. Moreover, the activation of CD8+ T cells by IL-2 is suppressed in the tumor
microenvironment (TME)
due to the acidic condition. Therefore, long-acting IL-2, which reduces IL-2Ra capability and
improves the antitumor activity of CD8+ T cells in the TME, is desired to enhance the therapeutic
efficacy of IL-2. Here, we developed IL-2 mutein, which has reduced IL-2Ra capability, and found
that IL-2 mutein
conjugated by cutting-edge PEG can improve antitumor activity of CD8+ T
cells in acidic conditions by in vitro assay, such as cell proliferation assay and cell killing
assay, rather than IL-2 mutein conjugated by conventional PEG.



NOF CORPORATION invites attendees to visit booth #712 to explore their innovative drug delivery solutions and engage with their experts.

For further information or to arrange a meeting, please refer to the following contact information.

Americas
NOF AMERICA CORPORATION
E-mail: info@nofamerica.com
Tel: New York Office: +1-914-681-9790
San Francisco Office: +1-650-993-7375
Boston Office: +1-914-704-7903


Europe
NOF EUROPE GmbH
E-mail: info-eu@nofeurope.com
Tel: +49 (0)69 7706 100 0

Asia Pacific, Japan
NOF CORPORATION
Life Science Division
E-mail: ddsinfo@nof.co.jp
Tel: +81-3-5424-6741

China
NOF (Shanghai) Co. Ltd.

Tel: +86-21-6210-1100