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Mono-functional Linear PEGs

Monofunctional Linear PEGs

The mono-functional SUNBRIGHT® series comprising highly purified methoxy PEG as the starting material contains negligible bifunctional PEG derived from diol impurities. Accordingly, bridging reactions (side reaction), an obstacle to PEGylation, can be completely prevented.

Hydrolysis ratio

of PEG-insulin (by using MeO-PEG-NHS type)

Hydrolysis test was conducted in pH 8 buffer solution at 4°C. Leaving insulin was measured by HPLC/UV.※HS type as well as AS type is stable (Hydrolysis test at 40°C).

Hydrolysis stability

• of activated ester and carbonate Linker

• of Maleimide group

• of Maleimide-Thiol conjugate

NHS active esters/Carbonate

SUNBRIGHT® CS, GS, AS, PS, HS and TS Series
We supply six types of monomethoxy-NHS activated ester/carbonate-PEGs that differ in terms of the NHS carboxylate attachment chemistry. The reactivity order of these linkers in aqueous solution from lowest to highest is HS<GS<TS<PS<CS<AS. After PEGylation, CS and GS types possessing ester groups are relatively susceptible to hydrolysis, whereas AS, PS, TS and HS types are resistant to hydrolysis because of their different chemical structures. Therefore, our customers can select the appropriate type according to their goals among the six types available.

CS Type

SUNBRIGHT® ME-050CS

Methoxy-PEG-CO(CH₂)₂COO-NHS, Mw 5,000
Chemical Name: α-Succinimidyloxysuccinyl-ω-methoxy, polyoxyethylene
CAS#: 78274-32-5
Packaging size: 1g/10g

SUNBRIGHT® ME-020CS

Methoxy-PEG-CO(CH₂)₂COO-NHS, Mw 2,000
Chemical Name: α-Succinimidyloxysuccinyl-ω-methoxy, polyoxyethylene
CAS#: 78274-32-5
Packaging size: 1g/10g

SUNBRIGHT® ME-100CS

Methoxy-PEG-CO(CH₂)₂COO-NHS, Mw 10,000
Chemical Name: α-Succinimidyloxysuccinyl-ω-methoxy, polyoxyethylene
CAS#: 78274-32-5
Packaging size: 1g/10g

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SUNBRIGHT® ME-200CS

Methoxy-PEG-CO(CH₂)₂COO-NHS, Mw 20,000
Chemical Name: α-Succinimidyloxysuccinyl-ω-methoxy, polyoxyethylene
CAS#: 78274-32-5
Packaging size: 1g/10g

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SUNBRIGHT® ME-400CS

Methoxy-PEG-CO(CH₂)₂COO-NHS, Mw 40,000
Chemical Name: α-Succinimidyloxysuccinyl-ω-methoxy, polyoxyethylene
CAS#: 78274-32-5
Packaging size: 1g/10g

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SUNBRIGHT® ME-300CS *

Methoxy-PEG-CO(CH₂)₂COO-NHS, Mw 30,000
Chemical Name: α-Succinimidyloxysuccinyl-ω-methoxy, polyoxyethylene
CAS#: 78274-32-5
Packaging size: 1g/10g

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GS Type

SUNBRIGHT® ME-050GS

Methoxy-PEG-CO(CH₂)₃COO-NHS, Mw 5,000
Chemical Name: α-Succinimidyloxyglutaryl-ω-methoxy, polyoxyethylene
CAS#: 111575-54-3
Packaging size: 1g/10g

SUNBRIGHT® ME-100GS

Methoxy-PEG-CO(CH₂)₃COO-NHS, Mw 10,000
Chemical Name: α-Succinimidyloxyglutaryl-ω-methoxy, polyoxyethylene
CAS#: 111575-54-3
Package size: 1g/10g

SUNBRIGHT® ME-200GS

Methoxy-PEG-CO(CH₂)₃COO-NHS, Mw 20,000
Chemical Name: α-Succinimidyloxyglutaryl-ω-methoxy, polyoxyethylene
CAS#: 111575-54-3
Packaging size: 1g/10g

SUNBRIGHT® ME-300GS

Methoxy-PEG-CO(CH₂)₃COO-NHS, Mw 30,000
Chemical Name: α-Succinimidyloxyglutaryl-ω-methoxy, polyoxyethylene
CAS#: 111575-54-3
Packaging size: 1g/10g

SUNBRIGHT® ME-400GS

Methoxy-PEG-CO(CH₂)₃COO-NHS, Mw 40,000
Chemical Name: α-Succinimidyloxyglutaryl-ω-methoxy, polyoxyethylene
CAS#: 111575-54-3
Package size: 1g/10g

AS Type

SUNBRIGHT® ME-020AS

Methoxy-PEG-CH₂COO-NHS, Mw 2,000
Chemical Name: Poly(oxy-1,2-ethanediyl), α-methyl-ω- {2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethoxy}-
CAS#: 92451-01-9
Packaging size: 1g/10g

SUNBRIGHT® ME-050AS

Methoxy-PEG-CH₂COO-NHS, Mw 5,000
Chemical Name: Poly(oxy-1,2-ethanediyl), α-methyl-ω- {2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethoxy}-
CAS#: 92451-01-9
Packaging size: 1g/10g

SUNBRIGHT® ME-100AS

Methoxy-PEG-CH₂COO-NHS, Mw 10,000
Chemical Name: Poly(oxy-1,2-ethanediyl), α-methyl-ω- {2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethoxy}-
CAS#: 92451-01-9
Packaging size: 1g/10g

SUNBRIGHT® ME-200AS

Methoxy-PEG-CH₂COO-NHS, Mw 20,000
Chemical Name: Poly(oxy-1,2-ethanediyl), α-methyl-ω- {2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethoxy}-
CAS#: 92451-01-9
Packaging size: 1g/10g

PS Type

SUNBRIGHT® ME-050PS

Mw 5,000

SUNBRIGHT® ME-200PS

Mw 20,000

HS Type

SUNBRIGHT® ME-050HS

Methoxy-PEG-(CH₂)₅COO-NHS, Mw 5,000
Chemical Name: Poly(oxy-1,2-ethanediyl), α-methyl-ω- {2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyloxy}-
CAS#: 212969-35-2
Packaging size: 1g/10g

SUNBRIGHT® ME-100HS

Methoxy-PEG-(CH₂)₅COO-NHS, Mw 10,000
Chemical Name: Poly(oxy-1,2-ethanediyl), α-methyl-ω- {2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyloxy}-
CAS#: 212969-35-2
Packaging size: 1g/10g

SUNBRIGHT® ME-200HS

Methoxy-PEG-(CH₂)₅COO-NHS, Mw 20,000
Chemical Name: Poly(oxy-1,2-ethanediyl), α-methyl-ω- {2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyloxy}-
CAS#: 212969-35-2
Packaging size: 1g/10g

SUNBRIGHT® ME-300HS

Methoxy-PEG-(CH₂)₅COO-NHS, Mw 30,000
Chemical Name: Poly(oxy-1,2-ethanediyl), α-methyl-ω- {2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyloxy}-
CAS#: 212969-35-2
Packaging size: 1g/10g

SUNBRIGHT® ME-400HS

Methoxy-PEG-(CH₂)₅COO-NHS, Mw 40,000
Chemical Name: Poly(oxy-1,2-ethanediyl), α-methyl-ω- {2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyloxy}-
CAS#: 212969-35-2
Packaging size: 1g/10g

TS Type

SUNBRIGHT® ME-050TS

Methoxy-PEG-COO-NHS, Mw 5,000
Chemical Name: α-Succinimidyl cabonyl-ω-methoxy, polyoxyethylene
CAS#: 135649-01-3
Packaging size: 1g / 10g

SUNBRIGHT® ME-100TS

Methoxy-PEG-COO-NHS, Mw 10,000
Chemical Name: α-Succinimidyl cabonyl-ω-methoxy, polyoxyethylene
CAS#: 135649-01-3
Packaging size: 1g / 10g

SUNBRIGHT® ME-120TS

Methoxy-PEG-COO-NHS, Mw 12000
Chemical Name: α-Succinimidyl cabonyl-ω-methoxy, polyoxyethylene
CAS#: 135649-01-3
Packaging size: 1g / 10g

SUNBRIGHT® ME-200TS

Methoxy-PEG-COO-NHS, Mw 20,000
Chemical Name: α-Succinimidyl cabonyl-ω-methoxy, polyoxyethylene
CAS#: 135649-01-3
Packaging size: 1g / 10g

SUNBRIGHT® ME-300TS

Methoxy-PEG-COO-NHS, Mw 30,000
Chemical Name: α-Succinimidyl cabonyl-ω-methoxy, polyoxyethylene
CAS#: 135649-01-3
Packaging size: 1g / 10g

SUNBRIGHT® ME-400TS

Methoxy-PEG-COO-NHS, Mw 40,000
Chemical Name: α-Succinimidyl cabonyl-ω-methoxy, polyoxyethylene
CAS#: 135649-01-3
Packaging size: 1g / 10g

SUNBRIGHT® NP Series (p-Nitrophenyl Carbonate PEG)

Reactive group: -CO₂-phenyl-NO2 Target groups: -NH2

SUNBRIGHT® NP Series (p-Nitrophenyl Carbonate PEG)

SUNBRIGHT® MENP-20H

Methoxy-PEG-COO-pNP, Mw 2,000
Chemical Name: α-Methoxy-ω-(4-nitrophenoxy carbonyl), polyoxyethylene
CAS#: 124661-64-9
Packaging size: 1g / 10g

SUNBRIGHT® MENP-50H

Methoxy-PEG-COO-pNP, Mw 5,000
Chemical Name: α-Methoxy-ω-(4-nitrophenoxy carbonyl), polyoxyethylene
CAS#: 124661-64-9
Packaging size: 1g / 10g

SUNBRIGHT® MENP-10T

Methoxy-PEG-COO-pNP, Mw 10,000
Chemical Name: α-Methoxy-ω-(4-nitrophenoxy carbonyl), polyoxyethylene
CAS#: 124661-64-9
Packaging size: 1g / 10g

SUNBRIGHT® MENP-20T

Methoxy-PEG-COO-pNP, Mw 20,000
Chemical Name: α-Methoxy-ω-(4-nitrophenoxy carbonyl), polyoxyethylene
CAS#: 124661-64-9
Packaging size: 1g / 10g

SUNBRIGHT® MENP-30T

Methoxy-PEG-COO-pNP, Mw 30,000
Chemical Name: α-Methoxy-ω-(4-nitrophenoxy carbonyl), polyoxyethylene
CAS#: 124661-64-9
Packaging size: 1g / 10g

SUNBRIGHT® MENP-40T

Methoxy-PEG-COO-pNP, Mw 40,000
Chemical Name: α-Methoxy-ω-(4-nitrophenoxy carbonyl), polyoxyethylene
CAS#: 124661-64-9
Packaging size: 1g / 10g

SUNBRIGHT® AL Series (Aldehyde PEG)

Exploiting our latest technologies, we supply mPEG aldehydes without any reactive problematic impurities (e.g. bifunctional aldehydes).

Reactive group: -CH₂CH₂-CHO Target groups: -NH2

SUNBRIGHT® AL Series (Aldehyde PEG)

SUNBRIGHT® ME-050AL

Methoxy-PEG-(CH₂)₂-CHO, Mw 5,000
Chemical Name: α-Methoxy-ω-(3-oxopropoxy), polyoxyethylene
CAS#: 125061-88-3
Packaging size: 1g/10g

SUNBRIGHT® ME-100AL

Methoxy-PEG-(CH₂)₂-CHO, Mw 10,000
Chemical Name: α-Methoxy-ω-(3-oxopropoxy), polyoxyethylene
CAS#: 125061-88-3
Packaging size: 1g/10g

SUNBRIGHT® ME-200AL

Methoxy-PEG-(CH₂)₂-CHO, Mw 20,000
Chemical Name: α-Methoxy-ω-(3-oxopropoxy), polyoxyethylene
CAS#: 125061-88-3
Packaging size: 1g/10g

SUNBRIGHT® ME-300AL

Methoxy-PEG-(CH₂)₂-CHO, Mw 30,000
Chemical Name: α-Methoxy-ω-(3-oxopropoxy), polyoxyethylene
CAS#: 125061-88-3
Packaging size: 1g/10g

SUNBRIGHT® ME-400AL2

Methoxy-PEG-(CH₂)₂-CHO, Mw 40,000
Chemical Name: α-Methoxy-ω-(3-oxopropoxy), polyoxyethylene
CAS#: 125061-88-3
Packaging size: 1g / 10g

SUNBRIGHT® PA Series (Aminopropyl PEG)

Reactive group: -CH₂CH₂CH₂NH2 Target groups: -COOH

SUNBRIGHT® PA Series (Aminopropyl PEG)

SUNBRIGHT® MEPA-20H

Methoxy-PEG-(CH₂)₃-NH₂, Mw 2,000
Chemical Name: α- Aminopropyl-ω-methoxy, polyoxyethylene
CAS#: 116164-53-5
Packaging size: 1g/10g

SUNBRIGHT® MEPA-50H

Methoxy-PEG-(CH₂)₃-NH₂, Mw 5,000
Chemical Name: α- Aminopropyl-ω-methoxy, polyoxyethylene
CAS#: 116164-53-5
Packaging size: 1g/10g

SUNBRIGHT® MEPA-10T

Methoxy-PEG-(CH₂)₃-NH₂, Mw 10,000
Chemical Name: α- Aminopropyl-ω-methoxy, polyoxyethylene
CAS#: 116164-53-5
Packaging size: 1g/10g

SUNBRIGHT® MEPA-12T

Methoxy-PEG-(CH2)3-NH2, Mw 12,000
Chemical Name: α- Aminopropyl-ω-methoxy, polyoxyethylene
CAS#: 116164-53-5
Packaging size: 1g/10g

SUNBRIGHT® MEPA-20T

Methoxy-PEG-(CH₂)₃-NH₂, Mw 20,000
Chemical Name: α- Aminopropyl-ω-methoxy, polyoxyethylene
CAS#: 116164-53-5
Packaging size: 1g/10g

SUNBRIGHT® MEPA-30T

Methoxy-PEG-(CH₂)₃-NH₂, Mw 30,000
Chemical Name: α- Aminopropyl-ω-methoxy, polyoxyethylene
CAS#: 116164-53-5
Packaging size: 1g/10g

SUNBRIGHT® MEPA-40T

Methoxy-PEG-(CH₂)₃-NH₂, Mw 40,000
Chemical Name: α- Aminopropyl-ω-methoxy, polyoxyethylene
CAS#: 116164-53-5
Packaging size: 1g/10g

SUNBRIGHT® EA Series (Aminoethyl PEG)

Reactive group: -CH₂CH₂NH2 Target groups: -COOH

SUNBRIGHT® EA Series (Aminoethyl PEG)

SUNBRIGHT® ME-050EA

Methoxy-PEG-(CH₂)₂-NH₂, Mw 5,000
Chemical Name: α- Aminoethyl-ω-methoxy, polyoxyethylene
CAS#: 80506-64-5
Packaging size: 1g/10g

SUNBRIGHT® ME-100EA

Methoxy-PEG-(CH₂)₂-NH₂, Mw 10,000
Chemical Name: α- Aminoethyl-ω-methoxy, polyoxyethylene
CAS#: 80506-64-5
Packaging size: 1g/10g

SUNBRIGHT® ME-200EA

Methoxy-PEG-(CH₂)₂-NH₂, Mw 20,000
Chemical Name: α- Aminoethyl-ω-methoxy, polyoxyethylene
CAS#: 80506-64-5
Packaging size: 1g/10g

SUNBRIGHT® ME-300EA

Methoxy-PEG-(CH₂)₂-NH₂, Mw 30,000
Chemical Name: α- Aminoethyl-ω-methoxy, polyoxyethylene
CAS#: 80506-64-5
Packaging size: 1g/10g

SUNBRIGHT® ME-400EA

Methoxy-PEG-(CH2)2-NH2, MW 40,000
Chemical Name: α- Aminoethyl-ω-methoxy, polyoxyethylene
CAS#: 80506-64-5
Packaging size: 1g/10g

SUNBRIGHT® ME-020EA

Methoxy-PEG-(CH₂)₂-NH₂, Mw 2,000
Chemical Name: α- Aminoethyl-ω-methoxy, polyoxyethylene
CAS#: 80506-64-5
Packaging size: 1g/10g

SUNBRIGHT® SH Series (Thiol PEG)

Reactive group: -CH₂CH₂SH Target groups: -SH,Maleimide,COOH

SUNBRIGHT® SH Series (Thiol PEG)

SUNBRIGHT® ME-020SH

Methoxy-PEG-(CH₂)₂-SH, Mw 2,000
Chemical Name: α-Mercaptoethyl-ω-methoxy, polyoxyethylene
CAS#: 134874-49-0
Packaging size: 1g/10g

SUNBRIGHT® ME-050SH

Methoxy-PEG-(CH₂)₂-SH, Mw 5,000
Chemical Name: α-Mercaptoethyl-ω-methoxy, polyoxyethylene
CAS#: 134874-49-0
Packaging size: 1g/10g

SUNBRIGHT® ME-100SH

Methoxy-PEG-(CH₂)₂-SH, Mw 10,000
Chemical Name: α-Mercaptoethyl-ω-methoxy, polyoxyethylene
CAS#: 134874-49
Packaging size: 1g/10g

SUNBRIGHT® ME-200SH

Methoxy-PEG-(CH₂)₂-SH, Mw 20,000
Chemical Name: α-Mercaptoethyl-ω-methoxy, polyoxyethylene
CAS#: 134874-49
Packaging size: 1g/10g

SUNBRIGHT® ME-300SH

Methoxy-PEG-(CH₂)₂-SH, Mw 30,000
Chemical Name: α-Mercaptoethyl-ω-methoxy, polyoxyethylene
CAS#: 134874-49
Packaging size: 1g/10g

SUNBRIGHT® ME-400SH

Methoxy-PEG-(CH₂)₂-SH, Mw 40,000
Chemical Name: α-Mercaptoethyl-ω-methoxy, polyoxyethylene
CAS#: 134874-49
Packaging size: 1g/10g

SUNBRIGHT® IA series (Iodoacetamide PEG)

Reactive group: CH₂CH₂CH₂NHCOCH₂I Target groups: -SH

SUNBRIGHT® IA series (Iodoacetamide PEG)

SUNBRIGHT® ME-200IA

Methoxy-PEG-(CH₂)₃NHCO-CH₂I, Mw 20,000
Chemical Name: α- Iodoacetamidopropyl-ω-methoxy, polyoxyethylene
CAS#: 1225327-74-1
Packaging size: 1g / 10g

SUNBRIGHT® ME-300IA

Methoxy-PEG-(CH₂)₃NHCO-CH₂I, Mw 30,000
Chemical Name: α- Iodoacetamidopropyl-ω-methoxy, polyoxyethylene
CAS#: 1225327-74-1
Packaging size: 1g / 10g

SUNBRIGHT® ME-400IA

Methoxy-PEG-(CH₂)₃NHCO-CH₂I, Mw 40,000
Chemical Name: α- Iodoacetamidopropyl-ω-methoxy, polyoxyethylene
CAS#: 1225327-74-1
Packaging size: 1g / 10g

SUNBRIGHT® MA Series (Maleimide PEG)

SUNBRIGHT® MA Series, C2 Type

SUNBRIGHT® ME-020MA

Methoxy-PEG-(CH₂)₃NHCO(CH₂)₂-MAL, Mw 2,000
Chemical Name: α-[3-(3-Maleimido-1-oxopropyl)amino]propyl-ω-methoxy, polyoxyethylene
CAS#: 883993-35-9
Packaging size: 1g / 10g

SUNBRIGHT® ME-050MA

Methoxy-PEG-(CH₂)₃NHCO(CH₂)₂-MAL, Mw 5,000
Chemical Name: α-[3-(3-Maleimido-1-oxopropyl)amino]propyl-ω-methoxy, polyoxyethylene
CAS#: 883993-35-9
Packaging size: 1g / 10g

SUNBRIGHT® ME-100MA

Methoxy-PEG-(CH₂)₃NHCO(CH₂)₂-MAL, Mw 10,000
Chemical Name: α-[3-(3-Maleimido-1-oxopropyl)amino]propyl-ω-methoxy, polyoxyethylene
CAS#: 883993-35-9
Packaging size: 1g / 10g

SUNBRIGHT® ME-200MA0B

Methoxy-PEG-(CH₂)₃NHCO(CH₂)₂-MAL, Mw 20,000
Chemical Name: α-[3-(3-Maleimido-1-oxopropyl)amino]propyl-ω-methoxy, polyoxyethylene
CAS#: 883993-35-9
Packaging size: 1g / 10g

SUNBRIGHT® ME-300MA

Methoxy-PEG-(CH₂)₃NHCO(CH₂)₂-MAL, Mw 30,000
Chemical Name: α-[3-(3-Maleimido-1-oxopropyl)amino]propyl-ω-methoxy, polyoxyethylene
CAS#: 883993-35-9
Packaging size: 1g / 10g

SUNBRIGHT® ME-400MA

Methoxy-PEG-(CH₂)₃NHCO(CH₂)₂-MAL, Mw 40,000
Chemical Name: α-[3-(3-Maleimido-1-oxopropyl)amino]propyl-ω-methoxy, polyoxyethylene
CAS#: 883993-35-9
Packaging size: 1g / 10g

SUNBRIGHT® MA Series, C5 Type

SUNBRIGHT® ME-050MA3 *

Methoxy-PEG-(CH₂)₃NHCO(CH₂)₅-MAL, Mw 5,000
Chemical Name: α-[3-(6-Maleimido-1-oxohexyl)amino]propyl-ω-methoxy, polyoxyethylene
CAS#:
Packaging size: 1g / 10g

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SUNBRIGHT® ME-100MA3 *

Methoxy-PEG-(CH₂)₃NHCO(CH₂)₅-MAL, Mw 10,000
Chemical Name: α-[3-(6-Maleimido-1-oxohexyl)amino]propyl-ω-methoxy, polyoxyethylene
CAS#:
Packaging size: 1g / 10g

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SUNBRIGHT® ME-200MA3 *

Methoxy-PEG-(CH₂)₃NHCO(CH₂)₅-MAL, Mw 20,000
Chemical Name: α-[3-(6-Maleimido-1-oxohexyl)amino]propyl-ω-methoxy, polyoxyethylene
CAS#:
Packaging size: 1g / 10g

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SUNBRIGHT® ME-400MA3 *

Methoxy-PEG-(CH₂)₃NHCO(CH₂)₅-MAL, Mw 40,000
Chemical Name: α-[3-(6-Maleimido-1-oxohexyl)amino]propyl-ω-methoxy, polyoxyethylene
CAS#:
Packaging size: 1g / 10g

^*make to order